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顶部生物活性储存和溶解信息计算器

Anti-Phospho-ER alpha (Ser118) Antibody (5S971)

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Anti-Phospho-ER alpha (Ser118) Antibody (5S971)
产品编号 TMAC-03214
别名 p-ER alpha (Ser118), p-ER alpha (S118), ER alpha (p-Ser118), ER alpha (p-S118)

Anti-Phospho-ER alpha (S118) Antibody (5S971) 是一种 Rabbit 抗体，靶向 Phospho-ER alpha (S118)。Anti-Phospho-ER alpha (S118) Antibody (5S971) 可用于 WB,ICC/IF,IHC。

Anti-Phospho-ER alpha (Ser118) Antibody (5S971)

Anti-Phospho-ER alpha (Ser118) Antibody (5S971)

Rating icon 还可以
Anti-Phospho-ER alpha (Ser118) Antibody (5S971)
产品编号 TMAC-03214 别名 p-ER alpha (Ser118), p-ER alpha (S118), ER alpha (p-Ser118), ER alpha (p-S118)

Anti-Phospho-ER alpha (S118) Antibody (5S971) 是一种 Rabbit 抗体，靶向 Phospho-ER alpha (S118)。Anti-Phospho-ER alpha (S118) Antibody (5S971) 可用于 WB,ICC/IF,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ER alpha (Ser118) Antibody (5S971) 是一种 Rabbit 抗体，靶向 Phospho-ER alpha (Ser118)。Anti-Phospho-ER alpha (Ser118) Antibody (5S971) 可用于 WB,ICC/IF,IHC。
别名p-ER alpha (Ser118), p-ER alpha (S118), ER alpha (p-Ser118), ER alpha (p-S118)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of Estrogen Receptor alpha (phospho S118) on MCF-7 cell lysates using anti-phospho-Estrogen Receptor alpha (S118) antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- phospho-Estrogen Receptor alpha (S118) antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti- phospho-Estrogen Receptor alpha (S118) antibody. Counter stained with hematoxylin.
4. ICC staining phospho-Estrogen Receptor alpha (S118) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining phospho-Estrogen Receptor alpha (S118) in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining phospho-Estrogen Receptor alpha (S118) in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
推荐剂量
WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Estrogen receptor alpha (ERa, ER, ESR, ESRA, Era, NR3A1, estrogen receptor 1) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. Alternative splicing results in several ERa mRNA transcripts, which differ primarily in their 5' untranslated regions. ERa undergoes phosphorylation in response to estradiol binding. Human ERa is predominately phosphorylated on Ser 118 and to a lesser extent on Ser 104 and Ser 106. In response to activation of the mitogen-activated protein kinase pathway, phosphorylation occurs on Ser 118 and Ser 167. These serine residues are all located within the activation function 1 region of the N-terminal domain of ERa. In contrast, activation of protein kinase A increases the phosphorylation of Ser 236, which is located in the DNA-binding domain. Src kinase-dependent Tyr 537 phosphorylation may enhance estrogen binding to ERa. Mutation of Tyr 537 of the human ERa produces receptors having a range of constitutive activity.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human Estrogen Receptor alpha around the phosphorylation site of Ser118
抗原种属
human
Uniprot ID
P03372
化学信息
分子量Theoretical: 66 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pER alpha (Ser118)pER alpha (S118)ER alpha (pSer118)ER alpha (pS118)ER alpha (phospho-Ser118)ER alpha (phospho-S118)

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