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Anti-Phospho-EGFR (Ser695) Antibody (1J343)

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Anti-Phospho-EGFR (Ser695) Antibody (1J343)
产品编号 TMAC-03207
别名 p-EGFR (Ser695), p-EGFR (S695), EGFR (p-Ser695), EGFR (p-S695)

Anti-Phospho-EGFR (S695) Antibody (1J343) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (S695)。Anti-Phospho-EGFR (S695) Antibody (1J343) 可用于 WB,ICC/IF。

Anti-Phospho-EGFR (Ser695) Antibody (1J343)

Anti-Phospho-EGFR (Ser695) Antibody (1J343)

Rating icon 还可以
Anti-Phospho-EGFR (Ser695) Antibody (1J343)
产品编号 TMAC-03207 别名 p-EGFR (Ser695), p-EGFR (S695), EGFR (p-Ser695), EGFR (p-S695)

Anti-Phospho-EGFR (S695) Antibody (1J343) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (S695)。Anti-Phospho-EGFR (S695) Antibody (1J343) 可用于 WB,ICC/IF。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-EGFR (Ser695) Antibody (1J343) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (Ser695)。Anti-Phospho-EGFR (Ser695) Antibody (1J343) 可用于 WB,ICC/IF。
别名p-EGFR (Ser695), p-EGFR (S695), EGFR (p-Ser695), EGFR (p-S695)
Ig Type
IgG
交叉反应
Human
验证活性
1. ICC staining Phospho-EGFR (S695) in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
2. ICC staining Phospho-EGFR (S695) in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining Phospho-EGFR (S695) in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
推荐剂量
WB: 1:1000; ICC/IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human EGFR around the phosphorylation site of Ser695
抗原种属
human
Uniprot ID
P00533
化学信息
分子量Theoretical: 134 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pEGFR (Ser695)pEGFR (S695)EGFR (pSer695)EGFR (pS695)EGFR (phospho-Ser695)EGFR (phospho-S695)

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4个月前
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