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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody

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货号 TMAB-10605

Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Dnmt3a (Ser390+Ser393)。Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody

Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10605

Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Dnmt3a (Ser390+Ser393)。Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Dnmt3a (Ser390+Ser393). Anti-Phospho-Dnmt3a (Ser390+Ser393) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
组织特异性Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human Dnmt3a around the phosphorylation site of Ser390 + Ser393
抗原种属
Human
基因名称
DNMT3A
基因ID
1788
蛋白名称
DNA(cytosine-5)-methyltransferase 3A
Uniprot ID
Q9Y6K1
功能
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
化学信息
分子量Theoretical: 102 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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