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Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody

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货号 TMAB-10588

Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-DDX58 (Thr170)。Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody

Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10588

Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-DDX58 (Thr170)。Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DDX58 (Thr170). Anti-Phospho-DDX58 (Thr170) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies.
组织特异性Present in vascular smooth cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human DDX58 around the phosphorylation site of Thr170
抗原种属
Human
基因名称
DDX58
基因ID
23586
蛋白名称
Antiviral innate immune response receptor RIG-I
Uniprot ID
O95786
功能
Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
化学信息
分子量Theoretical: 106 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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