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Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2
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还可以产品编号 TMAB-10584
Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-DDIT3 (Ser30)。Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。
Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2
Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-10584
Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-DDIT3 (Ser30)。Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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| 产品描述 | Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-DDIT3 (Ser30). Anti-Phospho-DDIT3 (Ser30) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| 交叉反应 | Human,Rat (predicted:Mouse,Dog,Pig,Cow,Rabbit,Sheep) |
| 应用 | IHC-PIHC-FrIFFCM |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. |
| 组织特异性 | Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]. Function : Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. |
| 免疫原 | KLH conjugated Synthesised phosphopeptide: human GADD153 around the phosphorylation site of Ser30 |
| 抗原种属 | Human |
| 基因名称 | DDIT3 |
| 基因ID | |
| 蛋白名称 | DNA damage-inducible transcript 3 protein |
| Uniprot ID | |
| 功能 | Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. |
| 分子量 | Theoretical: 19 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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