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Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2

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产品编号 TMAB-10565

Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Cyclin H (Thr315)。Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2

Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10565

Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Cyclin H (Thr315)。Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Cyclin H (Thr315). Anti-Phospho-Cyclin H (Thr315) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Human (predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human Cyclin H around the phosphorylation site of Thr315
抗原种属
Human
基因名称
CCNH
基因ID
902
蛋白名称
Cyclin-H
Uniprot ID
P51946
功能
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
化学信息
分子量Theoretical: 34 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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