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Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody

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货号 TMAB-10556

Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CXCR2 (Ser347)。Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody 可用于 WB。

Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody

Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10556

Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CXCR2 (Ser347)。Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CXCR2 (Ser347). Anti-Phospho-CXCR2 (Ser347) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Dog,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human CXCR2 around the phosphorylation site of Ser347
抗原种属
Human
基因名称
CXCR2
基因ID
3579
蛋白名称
C-X-C chemokine receptor type 2
Uniprot ID
P25025
功能
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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