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顶部生物活性储存和溶解信息计算器

Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody

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Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody
产品编号 TMAC-04341
别名 p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333), CTNNB1 (p-Tyr333)

Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CTNNB1 (Tyr333)。Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody

Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody
产品编号 TMAC-04341 别名 p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333), CTNNB1 (p-Tyr333)

Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CTNNB1 (Tyr333)。Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr333). Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody can be used in WB,IHC.
别名p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333), CTNNB1 (p-Tyr333)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from 293 cells untreated or treated with FSK using b-catenin (phospho-Tyr333) Antibody TMAC-04341.
2. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using β-catenin (phospho-Tyr333) Antibody TMAC-04341.
应用
WB
IHC
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 333 (Y-T-Y(p)-E-K) derived from Human b-catenin
抗原种属
human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pCTNNB1 (Y333)pCTNNB1 (Tyr333)CTNNB1 (pY333)CTNNB1 (pTyr333)CTNNB1 (phospho-Y333)CTNNB1 (phospho-Tyr333)

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