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Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody

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货号 TMAB-10552

Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CstF64 (Ser83)。Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody 可用于 WB。

Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody

Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10552

Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CstF64 (Ser83)。Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CstF64 (Ser83). Anti-Phospho-CstF64 (Ser83) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nuclear
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human CstF64 around the phosphorylation site of Ser83
抗原种属
Human
基因名称
CSTF2
基因ID
1478
蛋白名称
Cleavage stimulation factor subunit 2
Uniprot ID
P33240
功能
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
化学信息
分子量Theoretical: 61 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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