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Anti-Phospho-Chk1 (Ser345) Antibody (8E317)
还可以产品编号 TMAY-01574
Anti-Phospho-Chk1 (Ser345) Antibody (8E317) 是一种 Rabbit 抗体，靶向 Phospho-Chk1 (Ser345)。Anti-Phospho-Chk1 (Ser345) Antibody (8E317) 可用于 WB。
Anti-Phospho-Chk1 (Ser345) Antibody (8E317)
Anti-Phospho-Chk1 (Ser345) Antibody (8E317)
还可以产品编号 TMAY-01574
Anti-Phospho-Chk1 (Ser345) Antibody (8E317) 是一种 Rabbit 抗体，靶向 Phospho-Chk1 (Ser345)。Anti-Phospho-Chk1 (Ser345) Antibody (8E317) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-Chk1 (Ser345) Antibody (8E317) is a Rabbit antibody targeting Phospho-Chk1 (Ser345). Anti-Phospho-Chk1 (Ser345) Antibody (8E317) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8E317 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with Calyculin A (100 nM, 30 min; +), using Phospho-Chk1 (Ser345) rabbit monoclonal Antibody at 1:5000 dilution (upper) or Anti-beta-Actin Antibody Loading Control Antibody, Rabbit MAb (Chimeric) at 1:50000 dilution (lower). 2. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with Calyculin A (100 nM, 30 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-Chk1 (Ser345) rabbit monoclonal Antibody at 1:1000 dilution. (Validation Experiment) 3. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with calyculin A (100 nM, 30min; +) (line B); treated with calyculin A and λ-phosphatase (line C) using Phospho-Chk1 (Ser345) rabbit monoclonal Antibody at 1:1000 dilution. (Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:2000-1:20000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to residues around (Ser345) of Human Phospho-Chk1. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. There are two subtypes of chks that have so far been identified, CHK1 / CHEK1 and Chk2. They are essential components to delay cell cycle progression in normal and damaged cells and can act at all three cell cycle checkpoints. Chks are activated by phosphorylation. ATR kinase phosphorylates CHK1 / CHEK1 in response to single strand DNA breaks and ATM kinase phosphorylates Chk2 in response to double strand breaks. Chks phosphorylate Cdc25 phosphatase at Ser216, which leads to Cdc25 sequestration in the cytoplasm. Chks have a role in the physiological stress of hypoxia/reoxygenation. CHK1 / CHEK1 is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. CHK1 / CHEK1 may also negatively regulate cell cycle progression during unperturbed cell cycles.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to residues around (Ser345) of Human Phospho-Chk1 |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Tumor Suppressors |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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