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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Chk1 (Ser317) Antibody (5Q489)

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Anti-Phospho-Chk1 (Ser317) Antibody (5Q489)
产品编号 TMAY-01665
别名 Phospho-Chk1 (S317), p-Chk1 (Ser317), p-Chk1 (S317), OZEMA21, Chk1 (p-Ser317), Chk1 (p-S317), CHK-1

Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) 是一种 Rabbit 抗体，靶向 Phospho-Chk1 (Ser317)。Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) 可用于 WB,IHC-P。

Anti-Phospho-Chk1 (Ser317) Antibody (5Q489)

Anti-Phospho-Chk1 (Ser317) Antibody (5Q489)

Rating icon 还可以
Anti-Phospho-Chk1 (Ser317) Antibody (5Q489)
产品编号 TMAY-01665 别名 Phospho-Chk1 (S317), p-Chk1 (Ser317), p-Chk1 (S317), OZEMA21, Chk1 (p-Ser317), Chk1 (p-S317), CHK-1

Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) 是一种 Rabbit 抗体，靶向 Phospho-Chk1 (Ser317)。Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) 可用于 WB,IHC-P。

规格价格库存数量
20 μL
¥ 694
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100 μL
¥ 1,994
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产品介绍

生物活性
产品描述
Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) is a Rabbit antibody targeting Phospho-Chk1 (Ser317). Anti-Phospho-Chk1 (Ser317) Antibody (5Q489) can be used in WB,IHC-P.
别名Phospho-Chk1 (S317), p-Chk1 (Ser317), p-Chk1 (S317), OZEMA21, Chk1 (p-Ser317), Chk1 (p-S317), CHK-1
Ig Type
Rabbit IgG
克隆号
5Q489
交叉反应
Human
验证活性
1. Western blot analysis of extracts from serum-starved HEK293, untreated (-) or treated with UV (1 h; +), using Phospho-Chk1 (Ser317) rabbit Monoclonal Antibody at 1:2000 dilution (upper) or Beta-Tubulin Loading Control Antibody, Rabbit MAb (Chimeric) at 1:40000 dilution (lower).
2. Immunohistochemical analysis of paraffin-embedded human testis, untreated (left) or lambda phosphatase-treated (right), using Phospho-Chk1 (Ser317) Antibody, Rabbit Monoclonal at 1:1000 dilution.
3. Western blot analysis of extracts from serum-starved HEK293, untreated (line A); treated with UV (1 h), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-Chk1 (Ser317) rabbit monoclonal Antibody at 1:2000 dilution. (Validation Experiment)
4. Western blot analysis of extracts from serum-starved HEK-293, untreated (-) (line A); treated with UV (1 h; +) (line B); treated with UV and λ-phosphatase (line C) using Phospho-Chk1 (Ser317) rabbit monoclonal Antibody at 1:2000 dilution. (Validation Experiment)
应用
WB,IHC-P
推荐剂量
WB: 1:1000-1:2000; IHC-P: 1:500-1:2000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser317 of human Chk1.
纯化方式Protein A
性状Liquid
缓冲液10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
研究背景CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. There are two subtypes of chks that have so far been identified, CHK1 / CHEK1 and Chk2. They are essential components to delay cell cycle progression in normal and damaged cells and can act at all three cell cycle checkpoints. Chks are activated by phosphorylation. ATR kinase phosphorylates CHK1 / CHEK1 in response to single strand DNA breaks and ATM kinase phosphorylates Chk2 in response to double strand breaks. Chks phosphorylate Cdc25 phosphatase at Ser216, which leads to Cdc25 sequestration in the cytoplasm. Chks have a role in the physiological stress of hypoxia/reoxygenation. CHK1 / CHEK1 is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. CHK1 / CHEK1 may also negatively regulate cell cycle progression during unperturbed cell cycles.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: residues around Ser317 of human Chk1.
抗原种属
Human
研究领域
Cancer Drug Targets, Tumor Suppressors
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

pChk1 (Ser317)pChk1 (S317)Chk1 (pSer317)Chk1 (pS317)Chk1 (phospho-Ser317)Chk1 (phospho-S317)

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