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顶部生物活性储存和溶解信息计算器

Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2

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产品编号 TMAB-10484

Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-CDKN1B (Thr187)。Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2

Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10484

Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-CDKN1B (Thr187)。Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-CDKN1B (Thr187). Anti-Phospho-CDKN1B (Thr187) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
交叉反应
Human,Rat (predicted:Mouse,Dog,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 0.2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation.
组织特异性Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human CDKN1B around the phosphorylation site of Thr187
抗原种属
Human
基因名称
CDKN1B
基因ID
1027
蛋白名称
Cyclin-dependent kinase inhibitor 1B
Uniprot ID
P46527
功能
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
化学信息
分子量Theoretical: 22 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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