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Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody

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货号 TMAB-10408

Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-BNIP3 (Ser95)。Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody

Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10408

Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-BNIP3 (Ser95)。Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BNIP3 (Ser95). Anti-Phospho-BNIP3 (Ser95) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human (predicted:Dog,Cow,Horse,Sheep)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human BNIP3 around the phosphorylation site of Ser95
抗原种属
Human
基因名称
BNIP3
基因ID
664
蛋白名称
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Uniprot ID
Q12983
功能
Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.
化学信息
分子量Theoretical: 22 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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