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Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2
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还可以产品编号 TMAB-10371
Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-BAD (Ser91)。Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2
Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-10371
Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-BAD (Ser91)。Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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| 产品描述 | Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-BAD (Ser91). Anti-Phospho-BAD (Ser91) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Human |
| 应用 | IHC-PIHC-FrIF |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm. |
| 组织特异性 | Expressed in a wide variety of tissues. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
| 免疫原 | KLH conjugated synthesised phosphopeptide: human BAD around the phosphorylation site of Ser91 |
| 抗原种属 | Human |
| 基因名称 | BAD |
| 基因ID | |
| 蛋白名称 | Bcl2-associated agonist of cell death |
| Uniprot ID | |
| 功能 | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| 分子量 | Theoretical: 18 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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