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Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody

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货号 TMAB-10354

Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATG4D (Ser467)。Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody 可用于 WB。

Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody

Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10354

Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATG4D (Ser467)。Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATG4D (Ser467). Anti-Phospho-ATG4D (Ser467) Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cysteine protease ATG4D: Cytoplasm. Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
组织特异性Mainly expressed in skeletal muscle and, to a lower extent, in testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human ATG4D around the phosphorylation site of Ser467
抗原种属
Human
基因名称
ATG4D
基因ID
84971
蛋白名称
Cysteine protease ATG4D
Uniprot ID
Q86TL0
功能
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
化学信息
分子量Theoretical: 53 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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