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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2

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货号 TMAB-10341

Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Ataxin 1 (Ser775)。Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2

Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-10341

Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Ataxin 1 (Ser775)。Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Ataxin 1 (Ser775). Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus.
组织特异性Widely expressed throughout the body.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1).
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Ataxin 1 around the phosphorylation site of Ser776
抗原种属
Human
基因名称
ATXN1
基因ID
6310
蛋白名称
Ataxin-1
Uniprot ID
P54253
功能
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
化学信息
分子量Theoretical: 87 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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