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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody

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货号 TMAB-10310

Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-alpha B Crystallin (Ser59)。Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody

Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10310

Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-alpha B Crystallin (Ser59)。Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody is a Rabbit antibody targeting Phospho-alpha B Crystallin (Ser59). Anti-Phospho-alpha B Crystallin (Ser59) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig,Hamster)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
组织特异性Lens as well as other tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human alpha B Crystallin around the phosphorylation site of Ser59
抗原种属
Human
基因名称
CRYAB
基因ID
1410
蛋白名称
alpha-crystallin B chain
Uniprot ID
P02511
功能
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
化学信息
分子量Theoretical: 20 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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