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Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody

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Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody
产品编号 TMAC-00145
别名 p-ALK (Y1604), p-ALK (Tyr1604), ALK (p-Y1604), ALK (p-Tyr1604)

Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ALK (Tyr1604)。Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody

Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody
产品编号 TMAC-00145 别名 p-ALK (Y1604), p-ALK (Tyr1604), ALK (p-Y1604), ALK (p-Tyr1604)

Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ALK (Tyr1604)。Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ALK (Tyr1604). Anti-Phospho-ALK (Tyr1604) Polyclonal Antibody can be used in WB,IHC,IF.
别名p-ALK (Y1604), p-ALK (Tyr1604), ALK (p-Y1604), ALK (p-Tyr1604)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HepG2 cells, using ALK (Phospho-Tyr1604) antibody TMAC-00145. The lane on the right is treated with the synthesized peptide.
2. Western blot analysis of extracts from cos-7 cells (Lane 2), using ALK (Phospho-Tyr1604) Antibody TMAC-00145. The lane on the left is treated with synthesized peptide.
3. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ALK (Phospho-Tyr1604) antibody TMAC-00145. The picture on the right is treated with the synthesized peptide.
4. Immunofluorescence analysis of HeLa cells, using ALK (Phospho-Tyr1604) antibody TMAC-00145. The picture on the right is treated with the synthesized peptide.
应用
WB
IHC
IF
推荐剂量
WB: 1:500-3000; IHC: 1:50-100; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 1604 (G-H-Y(p)-E-D) derived from Human ALK
抗原种属
human
Uniprot ID
Q9UM73
化学信息
分子量Actual: 176 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pALK (Y1604)pALK (Tyr1604)ALK (pY1604)ALK (pTyr1604)ALK (phospho-Y1604)ALK (phospho-Tyr1604)

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