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Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody
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产品编号 TMAC-00143
别名 p-ALK (Y1507), p-ALK (Tyr1507), ALK (p-Y1507), ALK (p-Tyr1507)
Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ALK (Tyr1507)。Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody 可用于 WB。
Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody
Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody
还可以产品编号 TMAC-00143 别名 p-ALK (Y1507), p-ALK (Tyr1507), ALK (p-Y1507), ALK (p-Tyr1507)
Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ALK (Tyr1507)。Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,245 | 5日内发货 |
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| 产品描述 | Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ALK (Tyr1507). Anti-Phospho-ALK (Tyr1507) Polyclonal Antibody can be used in WB. |
| 别名 | p-ALK (Y1507), p-ALK (Tyr1507), ALK (p-Y1507), ALK (p-Tyr1507) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse |
| 验证活性 | 1. Western blot analysis of extracts from COS7 cells treated with Anisomycin using Phospho-ALK (Tyr1507) antibody TMAC-00143. The lane on the right is treated with the antigen-specific peptide. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of Tyrosine 1507 (P-T-Y(p)-G-S) derived from Human ALK |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 176 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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