Anti-Phospho-ALK (Tyr1278+Tyr128+Tyr1283) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ALK (Tyr1278+Tyr128+Tyr1283). Anti-Phospho-ALK (Tyr1278+Tyr128+Tyr1283) Polyclonal Antibody can be used in FCM.

IgG

Human (predicted:Mouse,Rat,Chicken,Dog,Cow,Horse)

FCM: 1μg/Test

Polyclonal

KLH conjugated Synthesised phosphopeptide: human ALK around the phosphorylation site of Tyr1278/1282/1283

Human

ALK

ALK tyrosine kinase receptor

Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction.