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顶部生物活性储存和溶解信息计算器

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

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产品编号 TMAC-00074

别名 p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659)

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ACSS2 (Ser659)。Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody 可用于 WB。

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAC-00074 别名 p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659)

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ACSS2 (Ser659)。Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,270
5日内发货
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产品描述
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.
别名p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659)
Ig Type
IgG
交叉反应
Human,Mouse
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
性状Liquid
研究背景Overcoming metabolic stress is a critical step in tumor growth. Acetyl coenzyme A (acetyl-CoA) generated from glucose and acetate uptake is important for his-tone acetylation and gene expression. However, how acetyl-CoA is produced under nutritional stress is un-clear. We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-medi-ated acetyl-CoA synthetase 2 (ACSS2) phosphoryla-tion at S659, which exposed the nuclear localization signal of ACSS2 for importin a5 binding and nuclear translocation. In the nucleus, ACSS2 binds to tran-scription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and pro-mote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. In addition, ACSS2 S659 phosphorylation positively correlates with AMPK ac-tivity in glioma specimens and grades of glioma malig-nancy. These results underscore the significance of nuclear ACSS2-mediated histone acetylation in main-taining cell homeostasis and tumor development.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human ACSS2 around the phosphorylation site of serine 659
抗原种属
human
化学信息
分子量Theoretical: 78 kDa.
颜色Transparent
物理性状Liquid
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pACSS2 (Ser659)pACSS2 (S659)ACSS2 (pSer659)ACSS2 (pS659)ACSS2 (phospho-Ser659)ACSS2 (phospho-S659)

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4个月前
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