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Anti-PDIA2 Polyclonal Antibody 2

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货号 TMAB-10130

Anti-PDIA2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PDIA2。Anti-PDIA2 Polyclonal Antibody 2 可用于 WB。

Anti-PDIA2 Polyclonal Antibody 2

Anti-PDIA2 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-10130

Anti-PDIA2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PDIA2。Anti-PDIA2 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-PDIA2 Polyclonal Antibody 2 is a Rabbit antibody targeting PDIA2. Anti-PDIA2 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum lumen.
组织特异性Highly expressed in pancreas (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PDIA2
抗原种属
Human
基因名称
PDIA2
基因ID
64714
蛋白名称
Protein disulfide-isomerase A2
Uniprot ID
Q13087
功能
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
化学信息
分子量Theoretical: 56 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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