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Anti-PDGFRA Antibody-APC (1K967)
还可以产品编号 TMAY-00967A
Anti-PDGFRA Antibody-APC (1K967) 是一种 APC-conjugated Mouse 抗体，靶向 PDGFRA。Anti-PDGFRA Antibody-APC (1K967) 可用于 FCM。
Anti-PDGFRA Antibody-APC (1K967)
Anti-PDGFRA Antibody-APC (1K967)
还可以产品编号 TMAY-00967A
Anti-PDGFRA Antibody-APC (1K967) 是一种 APC-conjugated Mouse 抗体，靶向 PDGFRA。Anti-PDGFRA Antibody-APC (1K967) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-PDGFRA Antibody-APC (1K967) is a APC-conjugated Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody-APC (1K967) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1K967 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human PDGFRα (CD140a) expression on MG63 cells. Cells were stained with APC-conjugated anti-Human PDGFRα (CD140a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PDGFRA / CD140a (rh PDGFRA / CD140a; TMPY-01139; NP_006197.1; Met1-Glu524) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human PDGFRA / CD140a Protein (TMPY-01139) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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