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Anti-PDGFC Antibody (4Y667)
还可以产品编号 TMAY-00544
Anti-PDGFC Antibody (4Y667) 是一种 Rabbit 抗体，靶向 PDGFC。Anti-PDGFC Antibody (4Y667) 可用于 ELISA,ICC/IF。
Anti-PDGFC Antibody (4Y667)
Anti-PDGFC Antibody (4Y667)
还可以产品编号 TMAY-00544
Anti-PDGFC Antibody (4Y667) 是一种 Rabbit 抗体，靶向 PDGFC。Anti-PDGFC Antibody (4Y667) 可用于 ELISA,ICC/IF。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-PDGFC Antibody (4Y667) is a Rabbit antibody targeting PDGFC. Anti-PDGFC Antibody (4Y667) can be used in ELISA,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4Y667 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of PDGFC in HepG2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human PDGFC monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus and Cytoplasm . |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human PDGF-C (rh PDGF-C ; TMPY-02815; NP_057289.1; Val235-Gly345). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. PDGF-C is involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human PDGF-C Protein (TMPY-02815) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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