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顶部生物活性储存和溶解信息计算器

Anti-PDGFC Antibody (4Y667)

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Anti-PDGFC Antibody (4Y667)
产品编号 TMAY-00544
别名 血小板源生长因子, platelet derived growth factor C, PDGF-C, AI647969, 1110064L01Rik

Anti-PDGFC Antibody (4Y667) 是一种 Rabbit 抗体，靶向 PDGFC。Anti-PDGFC Antibody (4Y667) 可用于 ELISA,ICC/IF。

Anti-PDGFC Antibody (4Y667)
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Anti-PDGFC Antibody (4Y667)

Rating icon 还可以
Anti-PDGFC Antibody (4Y667)
产品编号 TMAY-00544 别名 血小板源生长因子, platelet derived growth factor C, PDGF-C, AI647969, 1110064L01Rik

Anti-PDGFC Antibody (4Y667) 是一种 Rabbit 抗体，靶向 PDGFC。Anti-PDGFC Antibody (4Y667) 可用于 ELISA,ICC/IF。

规格价格库存数量
100 μL
¥ 2,284
5日内发货
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产品介绍

生物活性
产品描述
Anti-PDGFC Antibody (4Y667) is a Rabbit antibody targeting PDGFC. Anti-PDGFC Antibody (4Y667) can be used in ELISA,ICC/IF.
别名血小板源生长因子, platelet derived growth factor C, PDGF-C, AI647969, 1110064L01Rik
Ig Type
Rabbit IgG
克隆号
4Y667
交叉反应
Human
验证活性
Immunofluorescence staining of PDGFC in HepG2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human PDGFC monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus and Cytoplasm .
应用
ELISA,ICC/IF
推荐剂量
ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human PDGF-C (rh PDGF-C ; TMPY-02815; NP_057289.1; Val235-Gly345).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. PDGF-C is involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human PDGF-C Protein (TMPY-02815)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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AI-647969AI 647969

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