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Anti-PD-L1 Polyclonal Antibody
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产品编号 TMAB-01359
别名 Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Polyclonal Antibody 可用于 WB。
Anti-PD-L1 Polyclonal Antibody
Anti-PD-L1 Polyclonal Antibody
还可以产品编号 TMAB-01359 别名 Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,175 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-PD-L1 Polyclonal Antibody is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Pig,Cow,Horse,Sheep) |
| 验证活性 | Sample: Du145 (Human) Cell Lysate at 30 μg LOVO (Human) Cell Lysate at 30 μg Heart (Mouse) Lysate at 40 μg Muscle (Mouse) Lysate at 40 μg Heart (Rat) Lysate at 40 μg Primary: Anti-PD-L1 (TMAB-01359) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 50 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein. |
| 组织特异性 | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| 免疫原 | KLH conjugated synthetic peptide: human CD274 |
| 抗原种属 | Human |
| 基因名称 | CD274 |
| 基因ID | |
| 蛋白名称 | Programmed cell death 1 ligand 1 |
| Uniprot ID | |
| 研究领域 | Tumor antigens,Tumor-associated antigens,Non-lineage,Autoimmune,pd-l1 |
| 功能 | Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. |
| 分子量 | Theoretical: 32 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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