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Anti-PD-L1 Antibody-APC (7P10)
还可以产品编号 TMAY-03024A
Anti-PD-L1 Antibody-APC (7P10) 是一种 APC-conjugated Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Antibody-APC (7P10) 可用于 FCM。
Anti-PD-L1 Antibody-APC (7P10)
Anti-PD-L1 Antibody-APC (7P10)
还可以产品编号 TMAY-03024A
Anti-PD-L1 Antibody-APC (7P10) 是一种 APC-conjugated Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Antibody-APC (7P10) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PD-L1 Antibody-APC (7P10) is a APC-conjugated Rabbit antibody targeting PD-L1. Anti-PD-L1 Antibody-APC (7P10) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7P10 |
| 交叉反应 | Mouse |
| 验证活性 | Analysis of CD274 expression on spleen lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PD-L1 / B7-H1 / CD274 (rM PD-L1 / B7-H1 / CD274; TMPY-01155; NP_068693.1; Met1-Thr238) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD-L1 / B7-H1 / CImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD-L1 / B7-H1 / CD274 Immune Checkpoint ProteTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse PD-L1 / B7-H1 / CD274 protein (TMPY-01155) |
| 抗原种属 | Mouse |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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