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顶部生物活性储存和溶解信息计算器

Anti-PD-L1 Antibody (2Z518)

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产品编号 TMAB-01363
别名 Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik

Anti-PD-L1 Antibody (2Z518) 是一种 Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Antibody (2Z518) 可用于 WB。

Anti-PD-L1 Antibody (2Z518)

Anti-PD-L1 Antibody (2Z518)

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-01363 别名 Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik

Anti-PD-L1 Antibody (2Z518) 是一种 Rabbit 抗体，靶向 PD-L1。Anti-PD-L1 Antibody (2Z518) 可用于 WB。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-PD-L1 Antibody (2Z518) is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Antibody (2Z518) can be used in WB.
别名Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Ig Type
IgG
克隆号
2Z518
交叉反应
Human
验证活性
25 μg total protein per Lane of various lysates probed with PD-L1 monoclonal antibody, unconjugated (TMAB-01363) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.
verifiedActivity
应用WB
推荐剂量
WB: 1:200-1000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein.
组织特异性Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
抗原信息
免疫原
KLH conjugated synthetic peptide: human PD-L1
抗原种属
Human
基因名称
CD274
基因ID
29126
蛋白名称
Programmed cell death 1 ligand 1
Uniprot ID
Q9NZQ7
研究领域
Tumor antigens,Tumor-associated antigens,Non-lineage,Autoimmune,pd-l1
功能
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
化学信息
分子量Theoretical: 33 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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