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顶部生物活性储存和溶解信息计算器

Anti-PCNA Antibody (6Q348)

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产品编号 TMAH-00858

别名 proliferating cell nuclear antigen, ATLD2

Anti-PCNA Antibody (6Q348) 是一种抗体，靶向 PCNA。Anti-PCNA Antibody (6Q348) 可用于 ELISA,FCM。

Anti-PCNA Antibody (6Q348)

Anti-PCNA Antibody (6Q348)

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产品编号 TMAH-00858 别名 proliferating cell nuclear antigen, ATLD2

Anti-PCNA Antibody (6Q348) 是一种抗体，靶向 PCNA。Anti-PCNA Antibody (6Q348) 可用于 ELISA,FCM。

规格价格库存数量
50 μL
¥ 1,310
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-PCNA Antibody (6Q348) is an antibody targeting PCNA. Anti-PCNA Antibody (6Q348) can be used in ELISA,FCM.
别名proliferating cell nuclear antigen, ATLD2
Ig Type
Mouse IgG2a
克隆号
6Q348
交叉反应
Human
验证活性
Overlay Peak curve showing JK cells stained with TMAH-00858 (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
应用ELISAFCM
推荐剂量
FCM:1:20-1:500.
抗体种类
Monoclonal
亚细胞定位Nucleus.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human PCNA Protein
抗原种属
Human
基因名称
PCNA
基因ID
5111
Uniprot ID
P12004
研究领域
Isotype/Loading Controls, Epigenetics and Nuclear Signaling, Cancer, Cell biology, Tags & Cell Markers
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

ATLD-2ATLD 2

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