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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PAK6 Polyclonal Antibody

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货号 TMAB-09945

Anti-PAK6 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PAK6。Anti-PAK6 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-PAK6 Polyclonal Antibody

Anti-PAK6 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09945

Anti-PAK6 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PAK6。Anti-PAK6 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-PAK6 Polyclonal Antibody is a Rabbit antibody targeting PAK6. Anti-PAK6 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
组织特异性Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PAK6
抗原种属
Human
基因名称
PAK6
基因ID
56924
蛋白名称
Serine/threonine-protein kinase PAK 6
Uniprot ID
Q9NQU5
功能
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
化学信息
分子量Theoretical: 75 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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