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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575)

Synonyms: PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK
货号 TMAT-0961 一键复制产品信息
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Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) 是一种 Mouse 抗体，靶向 p44/42 MAPK (Erk1/2)。Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) 可用于 WB,IHC,IF,FCM。

Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0961

别名 PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK

Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) 是一种 Mouse 抗体，靶向 p44/42 MAPK (Erk1/2)。Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) 可用于 WB,IHC,IF,FCM。

Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575)
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产品介绍

生物活性
产品描述
Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) is a Mouse antibody targeting p44/42 MAPK (Erk1/2). Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) can be used in WB,IHC,IF,FCM.
别名
PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK
Ig Type
IgG2b
克隆号
6C575
反应种属
Human,Mouse,Rabbit
应用WBIHCIFFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液Ascitic fluid containing 0.03% sodium azide.
浓度1 mg/mL
研究背景Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human MAPK expressed in E. Coli.
抗原种属
Human
基因名称
MAPK1
基因ID
5594
蛋白名称
Mitogen-activated protein kinase 1
Uniprot ID
P28482
化学信息
分子量Theoretical: 42, 44 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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