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Anti-p130 Cas Antibody (8R644)

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货号 TMAB-09844

Anti-p130 Cas Antibody (8R644) 是一种 Rabbit 抗体，靶向 p130 Cas。Anti-p130 Cas Antibody (8R644) 可用于 WB,FCM。

Anti-p130 Cas Antibody (8R644)

Anti-p130 Cas Antibody (8R644)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09844

Anti-p130 Cas Antibody (8R644) 是一种 Rabbit 抗体，靶向 p130 Cas。Anti-p130 Cas Antibody (8R644) 可用于 WB,FCM。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-p130 Cas Antibody (8R644) is a Rabbit antibody targeting p130 Cas. Anti-p130 Cas Antibody (8R644) can be used in WB,FCM.
Ig Type
IgG
克隆号
8R644
反应种属
Human,Mouse,Rat
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation
组织特异性Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
抗原信息
基因名称
BCAR1
基因ID
9564
蛋白名称
Breast cancer anti-estrogen resistance protein 1
功能
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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