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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ORP4/OSBP2 Polyclonal Antibody

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货号 TMAB-09803

Anti-ORP4/OSBP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ORP4/OSBP2。Anti-ORP4/OSBP2 Polyclonal Antibody 可用于 WB。

Anti-ORP4/OSBP2 Polyclonal Antibody

Anti-ORP4/OSBP2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09803

Anti-ORP4/OSBP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ORP4/OSBP2。Anti-ORP4/OSBP2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-ORP4/OSBP2 Polyclonal Antibody is a Rabbit antibody targeting ORP4/OSBP2. Anti-ORP4/OSBP2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Peripheral membrane protein
组织特异性Expressed mainly in retina, testis, and fetal liver.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ORP4/OSBP2
抗原种属
Human
基因名称
OSBP2
基因ID
23762
蛋白名称
Oxysterol-binding protein 2
Uniprot ID
Q969R2
功能
Binds 7-ketocholesterol.
化学信息
分子量Theoretical: 101 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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