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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NSMase2 Polyclonal Antibody

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货号 TMAB-09649

Anti-NSMase2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NSMase2。Anti-NSMase2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

Anti-NSMase2 Polyclonal Antibody

Anti-NSMase2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-09649

Anti-NSMase2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NSMase2。Anti-NSMase2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-NSMase2 Polyclonal Antibody is a Rabbit antibody targeting NSMase2. Anti-NSMase2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit)
应用IHC-PIHC-FrIFELISA
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus membrane. Cell membrane. May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
组织特异性Predominantly expressed in brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景N-SMase2 (neutral sphingomyelinase 2), also known as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), is a ubiquitously expressed 655 amino acid member of the magnesium-dependent phosphohydrolase protein family. Localized to the membrane of the Golgi apparatus, N-SMase2 functions to catalyze the hydrolysis of sphingomyelin to form ceramide and phosphocholine—two proteins that mediate cell growth arrest and apoptosis. N-SMase2 is enzymatically activated by unsaturated fatty acids and phosphatidylserine and, through regulation of ceramide synthesis, is involved in growth suppression and postnatal development. Expression of N-SMase2 is upregulated during the G0/G1 phases of the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of 7.5. N-SMase2 deficiency is the cause of chondrodysplasia, a genetic disorder characterized by impaired bone growth that leads to short stature, bowlegs and underdeveloped joints.
抗原信息
免疫原
KLH conjugated synthetic peptide: human NSMase2
抗原种属
Human
基因名称
SMPD3
基因ID
55512
蛋白名称
Sphingomyelin phosphodiesterase 3
Uniprot ID
Q9NY59
功能
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
化学信息
分子量Theoretical: 71 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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