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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Notch1 Antibody (8D225)

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货号 TMAB-09570

Anti-Notch1 Antibody (8D225) 是一种 Rabbit 抗体，靶向 Notch1。Anti-Notch1 Antibody (8D225) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

Anti-Notch1 Antibody (8D225)

Anti-Notch1 Antibody (8D225)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09570

Anti-Notch1 Antibody (8D225) 是一种 Rabbit 抗体，靶向 Notch1。Anti-Notch1 Antibody (8D225) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Notch1 Antibody (8D225) is a Rabbit antibody targeting Notch1. Anti-Notch1 Antibody (8D225) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM.
Ig Type
IgG
克隆号
8D225
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIFICC/IFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:200-800; IHC-Fr: 1:200-800; IF: 1:200-800; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
组织特异性In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
A synthesized peptide: human Notch 1
抗原种属
Human
基因名称
NOTCH1
基因ID
4851
蛋白名称
Neurogenic locus notch homolog protein 1
Uniprot ID
P46531
功能
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.
化学信息
分子量Theoretical: 271 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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