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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NLE1 Polyclonal Antibody

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货号 TMAB-09513

Anti-NLE1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NLE1。Anti-NLE1 Polyclonal Antibody 可用于 WB。

Anti-NLE1 Polyclonal Antibody

Anti-NLE1 Polyclonal Antibody

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货号 TMAB-09513

Anti-NLE1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NLE1。Anti-NLE1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-NLE1 Polyclonal Antibody is a Rabbit antibody targeting NLE1. Anti-NLE1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nuclear, nucleolus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.
抗原信息
免疫原
KLH conjugated synthetic peptide: human NLE1
抗原种属
Human
基因名称
NLE1
基因ID
54475
蛋白名称
Notchless protein homolog 1
Uniprot ID
Q9NVX2
功能
NLE1 (Notchless protein homolog 1) contains 8 WD repeats and may be involved in the Notch signaling pathway.
化学信息
分子量Theoretical: 53 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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