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Anti-NKCC1/SLC12A2 Polyclonal Antibody

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货号 TMAB-09494

Anti-NKCC1/SLC12A2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NKCC1/SLC12A2。Anti-NKCC1/SLC12A2 Polyclonal Antibody 可用于 FCM。

Anti-NKCC1/SLC12A2 Polyclonal Antibody

Anti-NKCC1/SLC12A2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09494

Anti-NKCC1/SLC12A2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NKCC1/SLC12A2。Anti-NKCC1/SLC12A2 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-NKCC1/SLC12A2 Polyclonal Antibody is a Rabbit antibody targeting NKCC1/SLC12A2. Anti-NKCC1/SLC12A2 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Chimpanzee)
应用FCM
推荐剂量
FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Multi-pass membrane protein.
组织特异性Expressed in many tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.
抗原信息
免疫原
KLH conjugated synthetic peptide: human NKCC1
抗原种属
Human
基因名称
SLC12A2
基因ID
6558
蛋白名称
Solute carrier family 12 member 2
Uniprot ID
P55011
功能
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
化学信息
分子量Theoretical: 132 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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