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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Niemann Pick C1 Like 1 Antibody (1B639)

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货号 TMAB-09476

Anti-Niemann Pick C1 Like 1 Antibody (1B639) 是一种 Rabbit 抗体，靶向 Niemann Pick C1 Like 1。Anti-Niemann Pick C1 Like 1 Antibody (1B639) 可用于 WB。

Anti-Niemann Pick C1 Like 1 Antibody (1B639)

Anti-Niemann Pick C1 Like 1 Antibody (1B639)

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Rating icon 还可以
货号 TMAB-09476

Anti-Niemann Pick C1 Like 1 Antibody (1B639) 是一种 Rabbit 抗体，靶向 Niemann Pick C1 Like 1。Anti-Niemann Pick C1 Like 1 Antibody (1B639) 可用于 WB。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Niemann Pick C1 Like 1 Antibody (1B639) is a Rabbit antibody targeting Niemann Pick C1 Like 1. Anti-Niemann Pick C1 Like 1 Antibody (1B639) can be used in WB.
Ig Type
IgG
克隆号
1B639
反应种属
Human
应用WB
推荐剂量
WB: 1:1000-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
组织特异性Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Plays a major role in cholesterol homeostasis.Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte.Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol.Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia.
抗原信息
免疫原
A synthesized peptide: human NPC1L1
抗原种属
Human
基因名称
NPC1L1
基因ID
29881
蛋白名称
NPC1-like intracellular cholesterol transporter 1
Uniprot ID
Q9UHC9
功能
Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
化学信息
分子量Theoretical: 149 kDa. Actual: 149 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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