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Anti-NGFR/p75NTR Polyclonal Antibody

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货号 TMAB-09462

Anti-NGFR/p75NTR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NGFR/p75NTR。Anti-NGFR/p75NTR Polyclonal Antibody 可用于 FCM。

Anti-NGFR/p75NTR Polyclonal Antibody

Anti-NGFR/p75NTR Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09462

Anti-NGFR/p75NTR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NGFR/p75NTR。Anti-NGFR/p75NTR Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-NGFR/p75NTR Polyclonal Antibody is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,GuineaPig)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human NGFR
抗原种属
Human
基因名称
NGFR
基因ID
4804
蛋白名称
Tumor necrosis factor receptor superfamily member 16
Uniprot ID
P08138
功能
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
化学信息
分子量Theoretical: 44 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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