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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NFIP1 Polyclonal Antibody

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货号 TMAB-09433

Anti-NFIP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NFIP1。Anti-NFIP1 Polyclonal Antibody 可用于 WB。

Anti-NFIP1 Polyclonal Antibody

Anti-NFIP1 Polyclonal Antibody

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货号 TMAB-09433

Anti-NFIP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NFIP1。Anti-NFIP1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-NFIP1 Polyclonal Antibody is a Rabbit antibody targeting NFIP1. Anti-NFIP1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endosome membrane. Golgi apparatus membrane. Secreted. Detected in exosomes and secreted via the exosomal pathway.
组织特异性Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human NFIP1
抗原种属
Human
基因名称
NDFIP1
基因ID
80762
蛋白名称
NEDD4 family-interacting protein 1
Uniprot ID
Q9BT67
功能
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.
化学信息
分子量Theoretical: 25 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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