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Anti-Neutrophil Elastase Polyclonal Antibody

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货号 TMAB-09419

Anti-Neutrophil Elastase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Neutrophil Elastase。Anti-Neutrophil Elastase Polyclonal Antibody 可用于 WB,ICC/IF,FCM。

Anti-Neutrophil Elastase Polyclonal Antibody

Anti-Neutrophil Elastase Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09419

Anti-Neutrophil Elastase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Neutrophil Elastase。Anti-Neutrophil Elastase Polyclonal Antibody 可用于 WB,ICC/IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Neutrophil Elastase Polyclonal Antibody is a Rabbit antibody targeting Neutrophil Elastase. Anti-Neutrophil Elastase Polyclonal Antibody can be used in WB,ICC/IF,FCM.
Ig Type
IgG
反应种属
Human
应用WBICC/IFFCM
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Bone marrow cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
抗原信息
免疫原
Recombinant Protein: human Neutrophil Elastase protein
抗原种属
Human
基因名称
ELANE
基因ID
1991
蛋白名称
Neutrophil elastase
Uniprot ID
P08246
功能
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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