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Anti-Neuropilin-2 Antibody (3D949)
还可以产品编号 TMAY-01078
Anti-Neuropilin-2 Antibody (3D949) 是一种 Mouse 抗体，靶向 Neuropilin-2。Anti-Neuropilin-2 Antibody (3D949) 可用于 ELISA(Cap)。
Anti-Neuropilin-2 Antibody (3D949)
Anti-Neuropilin-2 Antibody (3D949)
还可以产品编号 TMAY-01078
Anti-Neuropilin-2 Antibody (3D949) 是一种 Mouse 抗体，靶向 Neuropilin-2。Anti-Neuropilin-2 Antibody (3D949) 可用于 ELISA(Cap)。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Neuropilin-2 Antibody (3D949) is a Mouse antibody targeting Neuropilin-2. Anti-Neuropilin-2 Antibody (3D949) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 3D949 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NRP2 / Neuropilin-2 (rh NRP2 / Neuropilin-2; TMPY-00892; NP_003863.2; Met1-Tyr855). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries. A recent study has identified NRP-2 as a polysialylation protein expressed in human dendritic cells and modulates DC-T Cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis, and metastasis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human NRP2 / Neuropilin-2 Protein (TMPY-00892) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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