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Anti-Neuropilin-1 Antibody (9D678)

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货号 TMAB-09407

Anti-Neuropilin-1 Antibody (9D678) 是一种 Rabbit 抗体，靶向 Neuropilin-1。Anti-Neuropilin-1 Antibody (9D678) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Neuropilin-1 Antibody (9D678)

Anti-Neuropilin-1 Antibody (9D678)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09407

Anti-Neuropilin-1 Antibody (9D678) 是一种 Rabbit 抗体，靶向 Neuropilin-1。Anti-Neuropilin-1 Antibody (9D678) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-Neuropilin-1 Antibody (9D678) is a Rabbit antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (9D678) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
9D678
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
组织特异性The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
抗原信息
免疫原
KLH conjugated synthetic peptide: human Neuropilin-1
抗原种属
Human
基因名称
NRP1
基因ID
8829
蛋白名称
Neuropilin-1
Uniprot ID
O14786
功能
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
化学信息
分子量Theoretical: 103 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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