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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Neuronatin Polyclonal Antibody

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货号 TMAB-09400

Anti-Neuronatin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Neuronatin。Anti-Neuronatin Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Neuronatin Polyclonal Antibody

Anti-Neuronatin Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09400

Anti-Neuronatin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Neuronatin。Anti-Neuronatin Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Neuronatin Polyclonal Antibody is a Rabbit antibody targeting Neuronatin. Anti-Neuronatin Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Pig,Cow,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The paternally imprinted Neuronatin gene (NNAT) is initially expressed in rhombomeres and the pituitary gland and is later expressed more widely, but much less abundantly, in the central and peripheral nervous systems. The human NNAT gene maps to chromosome 20q11.23 and contains an imprinting region associated with morphological abnormalities and early neonatal lethality. Specifically, hypermethylation of the NNAT gene occurs in both myeloid and lymphoid acute pediatric leukemias and may inhibit NNAT expression. The Neuronatin protein consists of two isoforms, alpha and beta, which are the products of alternative splicing. The alpha form of the Neuronatin gene is encoded by three exons, whereas the beta form is missing the second exon. Neuronatin mRNA expression is abundant in undifferentiated PC-12 cells. Treatment of these cells with nerve growth factor (NGF), which contributes to neuronal differentiation, downregulates Neuronatin mRNA expression. NNAT (-) 1.9 PC-12 cells exhibit an increase in nigericin, rotenone and valinomcin sensitivity; NNAT transfection restores wild-type PC-12 resistance. These results suggests a potential protective role for Neuronatin against toxic insult during development.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Neuronatin
抗原种属
Human
基因名称
NNAT
基因ID
4826
蛋白名称
Neuronatin
Uniprot ID
Q16517
功能
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.
化学信息
分子量Theoretical: 9 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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