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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-NEDD8 Antibody (6A250)

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货号 TMAC-02770

别名 Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8

Anti-NEDD8 Antibody (6A250) 是一种 Rabbit 抗体，靶向 NEDD8。Anti-NEDD8 Antibody (6A250) 可用于 ICC/IF,IHC,IP,WB。

Anti-NEDD8 Antibody (6A250)

Anti-NEDD8 Antibody (6A250)

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Rating icon 还可以
货号 TMAC-02770 别名 Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8

Anti-NEDD8 Antibody (6A250) 是一种 Rabbit 抗体，靶向 NEDD8。Anti-NEDD8 Antibody (6A250) 可用于 ICC/IF,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-NEDD8 Antibody (6A250) is a Rabbit antibody targeting NEDD8. Anti-NEDD8 Antibody (6A250) can be used in ICC/IF,IHC,IP,WB.
别名Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8
Ig Type
IgG
克隆号
6A250
反应种属
Human,Mouse,Rat
验证活性
1. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-NEDD8 antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-NEDD8 antibody. Counter stained with hematoxylin.
3. ICC staining NEDD8 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
verifiedActivityverifiedActivityverifiedActivity
应用ICC/IFIHCIPWB
推荐剂量
WB: 1:500-1000; IHC: 1:50-100; ICC/IF: 1:50-200; IP: 1:50
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景NEDD8 is a ubiquitin (Ub)-like molecule that shares 80% homology with ubiquitin, a protein known to modify and target various proteins for proteolytic degradation. NEDD8 and the corresponding yeast homolog Rub1 are activated by the E1 ubiquitin activating enzyme UBA2, which forms isopeptide linkages between thio esters. Similar to the Ub-mediated proteolytic pathway, NEDD8 is covalently coupled to an E3 Ub ligase by the E2 conjugating enzyme, Ubc12. NEDD8 preferentially associates with the CUL-2 protein in the E3 ligase complex CBCVHL, which consists of cullin proteins associating with elongin B/C and the tumor suppressor F-box protein, von Hippel Lindau (VHL). NEDD8 is predominantly localized to the nucleus and is highly expressed in adult heart and skeletal muscle. In vitro studies indicate that NEDD8 tetramers are also able to bind to the 26S Proteasome, and that they assemble into complexes with conserved Ub-like moieties, suggesting that NEDD8 may regulate proteolysis of intracellular proteins similar to other Ub-mediated pathways.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q15843
化学信息
分子量Theoretical: 9 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

NEDD-8NEDD 8
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