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Anti-NEDD8 Antibody (6A250)
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产品编号 TMAC-02770
别名 Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8
Anti-NEDD8 Antibody (6A250) 是一种 Rabbit 抗体，靶向 NEDD8。Anti-NEDD8 Antibody (6A250) 可用于 WB,ICC/IF,IHC,IP。
Anti-NEDD8 Antibody (6A250)
Anti-NEDD8 Antibody (6A250)
还可以产品编号 TMAC-02770 别名 Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8
Anti-NEDD8 Antibody (6A250) 是一种 Rabbit 抗体，靶向 NEDD8。Anti-NEDD8 Antibody (6A250) 可用于 WB,ICC/IF,IHC,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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抗原信息
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| 产品描述 | Anti-NEDD8 Antibody (6A250) is a Rabbit antibody targeting NEDD8. Anti-NEDD8 Antibody (6A250) can be used in WB,ICC/IF,IHC,IP. |
| 别名 | Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-NEDD8 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-NEDD8 antibody. Counter stained with hematoxylin. 3. ICC staining NEDD8 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-100; ICC/IF: 1:50-200; IP: 1:50 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | NEDD8 is a ubiquitin (Ub)-like molecule that shares 80% homology with ubiquitin, a protein known to modify and target various proteins for proteolytic degradation. NEDD8 and the corresponding yeast homolog Rub1 are activated by the E1 ubiquitin activating enzyme UBA2, which forms isopeptide linkages between thio esters. Similar to the Ub-mediated proteolytic pathway, NEDD8 is covalently coupled to an E3 Ub ligase by the E2 conjugating enzyme, Ubc12. NEDD8 preferentially associates with the CUL-2 protein in the E3 ligase complex CBCVHL, which consists of cullin proteins associating with elongin B/C and the tumor suppressor F-box protein, von Hippel Lindau (VHL). NEDD8 is predominantly localized to the nucleus and is highly expressed in adult heart and skeletal muscle. In vitro studies indicate that NEDD8 tetramers are also able to bind to the 26S Proteasome, and that they assemble into complexes with conserved Ub-like moieties, suggesting that NEDD8 may regulate proteolysis of intracellular proteins similar to other Ub-mediated pathways. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 9 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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