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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NALP12 Polyclonal Antibody

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货号 TMAB-09213

Anti-NALP12 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NALP12。Anti-NALP12 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-NALP12 Polyclonal Antibody

Anti-NALP12 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09213

Anti-NALP12 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NALP12。Anti-NALP12 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-NALP12 Polyclonal Antibody is a Rabbit antibody targeting NALP12. Anti-NALP12 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
抗原信息
免疫原
KLH conjugated synthetic peptide: human NALP12
抗原种属
Human
基因名称
NLRP12
基因ID
91662
蛋白名称
NACHT, LRR and PYD domains-containing protein 12
Uniprot ID
P59046
功能
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
化学信息
分子量Theoretical: 117 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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