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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MPRIP Polyclonal Antibody

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货号 TMAB-08973

Anti-MPRIP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MPRIP。Anti-MPRIP Polyclonal Antibody 可用于 WB。

Anti-MPRIP Polyclonal Antibody

Anti-MPRIP Polyclonal Antibody

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货号 TMAB-08973

Anti-MPRIP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MPRIP。Anti-MPRIP Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-MPRIP Polyclonal Antibody is a Rabbit antibody targeting MPRIP. Anti-MPRIP Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Horse,GuineaPig)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm; cytoskeleton. Colocalizes with F-actin.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景M-RIP is a 1,025 amino acid cytoplasmic and cytoskeletal protein that is required for regulation of the actin cytoskeleton. M-RIP colocalizes with myosin binding subunit (MBS) to regulate the phosphorylation of myosin light chain, and colocalizes with F-actin through its N-terminus in the cytoskeleton. M-RIP also interacts with and RhoA at actin stress fibers via its adjacent coiled coil domains. M-RIP is highly expressed in ovary, with moderate levels found in brain, heart, liver, lung, skeletal muscle, testis and kidney. M-RIP depletion causes an increase of stress fibers in smooth muscle cells, whereas M-RIP over-expression causes disassembly of stress fibers in neuronal cells. Containing two PH domains, M-RIP has multiple phosphorylated serine and threonine residues and exists as three isoforms which are produced by alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MPRIP
抗原种属
Human
基因名称
MPRIP
基因ID
23164
蛋白名称
Myosin phosphatase Rho-interacting protein
Uniprot ID
Q6WCQ1
功能
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
化学信息
分子量Theoretical: 117 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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