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Anti-MPL Monoclonal Antibody (5A673)

Synonyms: TPOR, MPLV, C-MPL, CD110
货号 TMAT-1010 一键复制产品信息
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Anti-MPL Monoclonal Antibody (5A673) 是一种 Mouse 抗体，靶向 MPL。Anti-MPL Monoclonal Antibody (5A673) 可用于 FCM。

Anti-MPL Monoclonal Antibody (5A673)

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货号 TMAT-1010

别名 TPOR, MPLV, C-MPL, CD110

Anti-MPL Monoclonal Antibody (5A673) 是一种 Mouse 抗体，靶向 MPL。Anti-MPL Monoclonal Antibody (5A673) 可用于 FCM。

Anti-MPL Monoclonal Antibody (5A673)
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产品介绍

生物活性
产品描述
Anti-MPL Monoclonal Antibody (5A673) is a Mouse antibody targeting MPL. Anti-MPL Monoclonal Antibody (5A673) can be used in FCM.
别名
TPOR, MPLV, C-MPL, CD110
Ig Type
IgG2b
克隆号
5A673
反应种属
Human
应用FCM
推荐剂量
FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human MPL expressed in E. Coli.
抗原种属
Human
基因名称
MPL
基因ID
4352
蛋白名称
Thrombopoietin receptor
Uniprot ID
P40238
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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