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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MMP14 Polyclonal Antibody

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货号 TMAB-08866

Anti-MMP14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MMP14。Anti-MMP14 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-MMP14 Polyclonal Antibody

Anti-MMP14 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-08866

Anti-MMP14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MMP14。Anti-MMP14 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-MMP14 Polyclonal Antibody is a Rabbit antibody targeting MMP14. Anti-MMP14 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Pig,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
组织特异性Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14. Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MMP14
抗原种属
Human
基因名称
MMP14
基因ID
4323
蛋白名称
Matrix metalloproteinase-14
Uniprot ID
P50281
功能
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
化学信息
分子量Theoretical: 54/62 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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