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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MLKL Polyclonal Antibody

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货号 TMAB-01149

别名 Mlkl, Mixed lineage kinase domain-like protein

Anti-MLKL Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MLKL。Anti-MLKL Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

Anti-MLKL Polyclonal Antibody

Anti-MLKL Polyclonal Antibody

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货号 TMAB-01149 别名 Mlkl, Mixed lineage kinase domain-like protein

Anti-MLKL Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MLKL。Anti-MLKL Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

生物活性
产品描述
Anti-MLKL Polyclonal Antibody is a Rabbit antibody targeting MLKL. Anti-MLKL Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
别名Mlkl, Mixed lineage kinase domain-like protein
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
验证活性
Sample:
Lane 1: Human HeLa cell lysates
Lane 2: Human MCF-7 cell lysates
Primary: Anti-MLKL (TMAB-01149) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 50 kDa
verifiedActivity
应用IFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
抗原信息
免疫原
Recombinant Protein: protein of mouse MLKL
抗原种属
Mouse
基因名称
MLKL
基因ID
74568
蛋白名称
Mixed lineage kinase domain-like protein
Uniprot ID
Q9D2Y4
研究领域
Necroptosis,SARS Coronavirus,Other Kinases
功能
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
化学信息
分子量Theoretical: 54 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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