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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-MLH1 Monoclonal Antibody (6I965)

Synonyms: HNPCC, FCC2, COCA2
货号 TMAT-1011 一键复制产品信息
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Anti-MLH1 Monoclonal Antibody (6I965) 是一种 Mouse 抗体，靶向 MLH1。Anti-MLH1 Monoclonal Antibody (6I965) 可用于 WB,IHC,IF。

Anti-MLH1 Monoclonal Antibody (6I965)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1011

别名 HNPCC, FCC2, COCA2

Anti-MLH1 Monoclonal Antibody (6I965) 是一种 Mouse 抗体，靶向 MLH1。Anti-MLH1 Monoclonal Antibody (6I965) 可用于 WB,IHC,IF。

Anti-MLH1 Monoclonal Antibody (6I965)
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产品介绍

生物活性
产品描述
Anti-MLH1 Monoclonal Antibody (6I965) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (6I965) can be used in WB,IHC,IF.
别名
HNPCC, FCC2, COCA2
Ig Type
IgG1
克隆号
6I965
反应种属
Human,Monkey
应用WBIHCIF
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
抗原种属
Human
基因名称
MLH1
基因ID
4292
蛋白名称
DNA mismatch repair protein Mlh1
Uniprot ID
P40692
化学信息
分子量Theoretical: 85 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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